Free Content Distribution and antibiotic susceptibility of Shigella isolates in Bangui, Central African Republic

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Abstract:

Summary We conducted a prospective study in four urban health care centres between January 2004 and November 2005 to determine the distribution and susceptibility patterns of strains causing invasive diarrhoea in Bangui, Central African Republic. Of the 155 isolated, (51%) and (30%) were the most common and the most resistant to usual antibiotics, including amoxicillin, sulphamethoxazole–trimethoprim and chloramphenicol. Though multi-drug resistance was common, no strains were resistant to quinolone and fluoroquinolones. We conclude that short-course treatments with ciprofloxacin can be recommended in Bangui for treatment of invasive diarrhoea.

French
Nous avons effectué une étude prospective dans quatre centres de santé urbains, entre janvier 2004 et novembre 2005 afin de déterminer les profils de distribution et de sensibilité des souches de Shigella causant des diarrhées invasives à Bangui, en République Centrafricaine. Sur les 155 souches de Shigella isolées, S. flexneri (51%) et S. dysenteriae (30%) étaient les plus courantes et les plus résistantes aux antibiotiques d’usage notamment l’amoxicilline, le sulfaméthoxazol-triméthoprime et le chloramphénicol. Bien que des résistances multiples aux médicaments étaient courantes, aucune souche n’était résistante aux quinolones ni aux fluoroquinolones. Nous concluons que les traitements de courte durée avec la ciprofloxacine pourraient être recommandés à Bangui dans les diarrhées invasives.

Keywords: Afrique centrale; Central Africa; Shigella; diarrea; diarrhoea; diarrhée; África Central

Document Type: Short Communication

DOI: http://dx.doi.org/10.1111/j.1365-3156.2008.02023.x

Affiliations: 1:  Institut Pasteur de Bangui, Bangui, Central African Republic 2:  Complexe Pédiatrique de Bangui, Bangui, Central African Republic

Publication date: April 1, 2008

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