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Free Content Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso

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Abstract:

Summary We investigated the relationship between the two main molecular markers for chloroquine resistance ( T76 and Y86) and the clinical efficacy of amodiaquine in Burkina Faso. Before treatment, the prevalence of T76, Y86 or both mutations in the same infection was significantly higher in patients who experienced a recrudescence than in those who successfully responded to the treatment. Therefore, these two molecular markers could be useful in monitoring amodiaquine resistance, particularly in countries where this drug is used in combination with artesunate as first- or second-line treatment.

French
Nous avons investigué la relation entre les deux principaux marqueurs moléculaires pour la résistance à la chloroquine (Pfcrt T76 et Pfmdr-1 Y86) et l’efficacité clinique de l’amodiaquine au Burkina-Faso. Avant traitement, la prévalence de Pfcrt T76, Pfmdr-1 Y86 ou les deux mutations à la fois dans la même infection étaient sensiblement plus élevée chez les patients qui ont connu une recrudescence que chez ceux qui ont répondu au traitement. Par conséquent, ces 2 marqueurs moléculaires pourraient être utiles dans la surveillance de la résistance à l’amodiaquine, en particulier dans les pays où ce médicament est utilisé en combinaison avec l’artésunate comme traitement de première ou seconde ligne.

Keywords: P. falciparum; Pfcrt; Pfmdr-1; Plasmodium falciparum; amodiaquina; amodiaquine; drug resistance; malaria; resistencia a medicamentos; résistance aux médicaments

Document Type: Short Communication

DOI: https://doi.org/10.1111/j.1365-3156.2007.01995.x

Affiliations: 1:  Centre Muraz, Bobo Dioulasso, Burkina Faso 2:  Institut de Recherche en Sciences de la Santé (IRSS), Bobo Dioulasso, Burkina Faso 3:  Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium

Publication date: 2008-02-01

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