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Free Content Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents

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Abstract:

Summary Objective  To determine the specificity of the Abbott Murex HIV antigen/antibody combination enzyme immunoassay (EIA) for the diagnosis of HIV infection in Tanzania. Methods  A cross-sectional survey of 7333 Tanzanian adolescents and young adults was carried out. Sera testing positive by the Murex assay were further evaluated using a battery of other EIA which detect either antibody to HIV-1 or p24 antigen, and by PCR using primers. Results  Of the 674 sera testing positive by the Murex assay, only 53 (7.9%) were confirmed. The specificity of the Murex assay was 91.5%. Conclusions  Serological tests for HIV may perform differently in different populations. New diagnostic tests should not be introduced into populations in which they have not been evaluated.

French
Spécificité faible du test Murex EIA quatrième génération pour le VIH chez les adolescents tanzaniens Objectif: 

Déterminer la spécificité du test enzymatique Murex EIA (Abbott) combiné Ag/Ac pour le diagnostic de l’infection par le VIH en Tanzanie. Méthodes: 

Surveillance transversale de 7333 adolescents et jeunes adultes tanzaniens. Des sera trouvés positifs par le test de Murex ont été de nouveau évalués à l’aide d’une panoplie d’autres tests EIAs qui détectent soit des anticorps du VIH-1 soit des antigènes p24, et par PCR à l’aide d’amorces pol. Résultats: 

Sur 674 sera trouvés positif par le test Murex, seuls 53 (7,9%) ont été confirmés. La spécificité du test Murex était 91,5%. Conclusions: 

Les tests sérologiques pour le VIH peuvent réagir différemment sur différentes populations. De nouveaux tests de diagnostic ne devraient pas être introduits dans les populations dans lesquelles ils n’ont pas étéévalués.

Keywords: Africa; Afrique; HIV tests; Test VIH; especificidad; false positives; falsos positivos; faux positifs; pruebas VIH; specificity; spécificité; África

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2007.01933.x

Affiliations: 1:  London School of Hygiene & Tropical Medicine, London, UK 2:  National Institute for Medical Research, Mwanza, Tanzania 3:  Centre for Infections, Health Protection Agency, London, UK

Publication date: November 1, 2007

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