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Free Content Evaluation of immunodiagnostics for toxocarosis in experimental porcine cysticercosis

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Summary We assessed whether immunodiagnostic tests for cysticercosis can cross-react with the currently available immunodiagnostic tests for in an established animal model for cysticercosis infection in pigs, known host for . We examined by TES-enzyme-linked immunosorbent test and immunoblot assay for toxocarosis and cysticercosis the baseline and final follow-up sera of 10 pigs, before and after (3 months) infection with . After successful cysticercosis infection, the nine evaluable pigs became seropositive to (enzyme-linked immunoelectrotransfer blot assay), but did remain seronegative for in both assays, documenting the lack of cross-reactivity with anti- antibodies in both assays. These findings should help clinicians better interpret serology for toxocariosis and cysticercosis in endemic areas for both helminth infections.

Nous avons évalué si les tests de diagnostic immunologique de la cysticercose pouvaient avoir des réactions croisées avec le test immunologique actuellement disponible de Toxocara canis dans un modèle animal établi pour l'infection de la cysticercose chez le porc, hôte connu de Toxocara. Nous avons examiné par test ELISA et par un test sur immunoblot pour toxocarose et cysticercose le sang de 10 porcs a la base et a la fin du suivi, avant et après (trois mois) d'infection avec Taenia solium. A la suite d'une infection efficace de cysticercose, les 9 porcs évaluables sont devenus séropositifs pour T. solium (test enzymatique par immunoelectrotransfert) mais sont restés séronégatifs pour Toxocara pour tous les tests. Cela révèle donc le manque de réaction croisée avec les anticorps anti-T. solium dans les deux tests pour T. canis. Ces observations devraient aider les cliniciens a mieux interpréter la sérologie de toxocarose et cysticercose dans les régions endémiques pour les deux helminthoses.
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Keywords: cerdo; cisticercosis; cysticercose; cysticercosis; diagnostic immunologique; epilepsia; epilepsy; immunodiagnosis; inmunodiagnóstico; pig; porc; toxocarose; toxocarosis; épilepsie

Document Type: Research Article

Affiliations: 1:  Dipartimento di Scienze di Sanità Pubblica, Università degli Studi di Roma ‘La Sapienza’, Rome, Italy 2:  Clinica Malattie Infettive, Università degli Studi di Firenze, Florence, Italy 3:  Cysticercosis Unit, Instituto de Ciencias Neurologicas, Lima, Peru 4:  Department of Microbiology, Universidad Peruana Cayetano Heredia, San Martin de Porres, Lima, Peru 5:  Dipartimento di Neuroscienze, Università degli Studi di Catania, Catania, Italy

Publication date: 2007-01-01

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