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Free Content Estimates of intraclass correlation coefficient and design effect for surveys and cluster randomized trials on injection use in Pakistan and developing countries

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Abstract:

Summary Background  To assess injection practices and to test interventions aimed at reducing unsafe injections in developing countries, cluster surveys and cluster randomized trials are needed. The design of cluster-based studies requires estimates of intraclass correlation coefficients that have to be obtained from previous studies. This study presents such estimates. Methods  Data were derived from a cross-sectional study of injection use and health seeking in Pakistan that used 34 clusters to select 1150 study subjects aged ≥3 months. We analysed variance to separate its components. Results  Most of intraclass correlation coefficients were in the range of 0.01–0.05. For proportion of injections received during last 3 months, mean number of injections received and health seeking during the past 3 months the intraclass correlation coefficients were 0.02, 0.04 and 0.02, respectively. Conclusion  These estimates can be useful in designing cluster surveys and cluster randomized trials for injection safety in Pakistan and other developing countries.

French
Données de base 

Afin d’évaluer les pratiques d'injection et de tester les interventions visant à réduire les injections à risque dans les pays en développement, des études de surveillance et des essais randomisés en grappes sont nécessaires. La conception des essais en grappes nécessite une estimation des coefficients de corrélations intra-classe obtenus à partir d’études précédentes. Cette étude présente de telles estimations. Méthodes 

Les données proviennent d'une étude transversale sur les pratiques d'injections et le recours aux soins au Pakistan, basée sur 34 grappes pour la sélection de 1150 sujets âgés de ≥3 mois. Nous avons analysé la variance pour séparer les composants. Résultats 

La plupart des coefficients de corrélation intra-classe étaient dans la marge de 0,01 à 0,05. sur base de la proportion d'injections reçues durant les trois derniers mois, du nombre moyen d'injections reçues et des recours au traitement durant les trois derniers mois, les coefficients de corrélation intra-classe étaient respectivement de 0,02; 0,04 et 0,02. Conclusion 

Ces estimations peuvent être utiles dans la conception d’études de surveillance ou d'essais randomisés en grappes sur la sûreté des injections au Pakistan et dans d'autres pays en développement.

Keywords: Coefficients de Corrélation Intra-classe; Coeficientes de correlación intraclase; Intraclass correlation coefficients; Pakistan; Paquistán; analyse en grappes; análisis de cluster; cluster analysis; concept d’étude; diseño del estudio; injection practices; inyecciones; pratiques de l'injection; prácticas con inyecciones; research design; sample size; taille d’échantillon; tamaño de muestra

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2006.01736.x

Affiliations: 1:  Department of Pediatrics, Aga Khan University, Karachi, Pakistan 2:  International Vaccine Institute, Seoul, South Korea

Publication date: December 1, 2006

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