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Free Content Invasive pneumococcal disease in children <5 years of age in rural Mozambique

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Abstract:

Summary Objectives 

To estimate the incidence and epidemiological characteristics of invasive pneumococcal disease (IPD) in children <5 years of age living in a rural area of southern Mozambique. Methods 

As part of the clinical management of children admitted to Manhiça District Hospital, prospective surveillance for invasive bacterial disease was conducted from June 2001 to May 2003. The level of antibiotic resistance of the isolates was also analysed. Results 

Pneumococcus was the most commonly isolated bacterium, accounting for 212 episodes. The estimated crude incidence rate of IPD in the study area among children <5 years of age was 416/100 000 per child-year at risk. The youngest age group (<3 months) had the highest incidence (779/100 000). Cases were detected during both rainy and dry seasons. The most common clinical diagnosis was pneumonia, made in 146/212 (69%) of the episodes of IPD. The overall case fatality rate was 10%, being highest among children with pneumococcal meningitis (5/9 = 56%). Pneumococcal isolates were highly susceptible to penicillin (86% susceptible and 14% with intermediate resistance) and chloramphenicol (98% susceptible). In contrast, up to 37% of the isolates tested were non-susceptible to cotrimoxazole. Conclusions 

Incidence rates of IPD and associated mortality shown in this study highlight the need for pneumococcal vaccines in rural Africa, which must be effective in infants and young children.

Keywords: Africa; Pneumococcus; clinical presentation; incidence; invasive pneumococcal disease

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2006.01697.x

Affiliations: 1:  Centro de Investigação em Saúde da Manhiça, Ministério de Saúde, Maputo, Mozambique 2:  Center for Vaccine Development, University of Maryland, School of Science, Baltimore, MD, USA

Publication date: 2006-09-01

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