Skip to main content

Free Content Comparison of cytokine plasma levels in human African trypanosomiasis

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Abstract:

Summary Background 

Immunological studies suggest that human African trypanosomiasis (HAT) is associated with inflammatory responses. A better understanding of the complex cytokine interactions regulating HAT infections is essential to elucidate the mechanisms of generalized immunosuppression. Method 

We determined levels of interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor (TNF)-α and interferon (IFN)-γ protein levels in plasma samples from three groups of individuals from the Democratic Republic of Congo: (i) HAT cases; (ii) seropositive individuals for whom parasite detection was negative and (ii) controls. Results 

Plasma levels of six cytokines were significantly higher in HAT cases than in both controls (P < 0.003) and seropositive individuals (P < 0.016). IL-2 and IL-10 concentrations were significantly lower (P < 0.02) in the seropositive group than in the control one. Conclusion 

Human African trypanosomiasis leads to the development of strong cytokine responses, indicating the potential involvement of IL-2 and IL-10 in the phenomenon of seropositivity without parasitological confirmation. This strongly suggests the involvement of immunity in this particular aspect of HAT epidemiology.

Keywords: Trypanosoma brucei gambiense; gamma interferon; human African trypanosomiasis; interleukin; tumour necrosis factor-alpha

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2006.01612.x

Affiliations: 1:  Institut de Recherche pour le Développement, Santé de la mère et de l'enfant en milieu tropical, Paris, France 2:  Institut de Recherche pour le Développement, Interactions hôtes-vecteurs-parasites dans les trypanosomoses, Montpellier, France 3:  Becton Dickinson Biosciences, Le-Pont-de-Claix, France 4:  Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Kinshasa, République Démocratique du Congo 5:  Ministère de la Santé, Kinshasa, République Démocratique du Congo 6:  Institut de Recherche pour le Développement, Santé de la mère et de l'enfant en milieu tropical, Cotonou, Benin

Publication date: 2006-05-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more