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Free Content Short communication: Trypanosoma cruzi lineage I in endomyocardial biopsy from a north-eastern Brazilian patient at end-stage chronic chagasic cardiomyopathy

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Abstract:

Summary

Trypanosoma cruzi, the agent of Chagas disease, is genetically classified into two major evolutionary lineages, T. cruzi I and T. cruzi II. In Southern American Cone countries it is T cruzi II which causes most cases of severe chronic Chagas disease. Contrary to this, we isolated T. cruzi I nested in endomyocardial biopsies of a chronic chagasic patient with end-stage heart failure. Our finding should alert clinicians to the possibility of severe Chagas disease in all regions where T. cruzi circulates, regardless of its lineage.

Keywords: Chagas disease; T. cruzi lineages; Trypanosoma cruzi; cardiomyopathy; endomyocardial biopsy; genetic typing

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2006.01575.x

Affiliations: 1: Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil 2: Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil 3: Laboratório de Imunologia, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil 4: Divisão de Cirurgia, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil

Publication date: 2006-03-01

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