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Free Content High frequency of multidrug-resistant Mycobacterium tuberculosis isolates in Georgetown, Guyana

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Abstract:

Summary

Emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis isolates constitutes a threat to public health worldwide. This study aimed at acquiring first epidemiological data for Guyana. Thirty-six M. tuberculosis isolates from patients of the Georgetown Chest Clinic were subjected to susceptibility testing on solid agar and in broth media. Resistance to at least one first-line drug was observed in 8 (22.2%, 95% confidence interval 8.3–36.1%) and simultaneous resistance to rifampicin and isoniazid (MDR) in 4 (11.1%, 95% confidence interval 0.6–21.6%) of the 36 isolates. The risk of infection with resistant isolates was significantly related to earlier antituberculosis therapy (P = 0.040). These data indicate a high proportion of resistant M. tuberculosis isolates in Guyana and call for the implementation of control strategies based on an improved laboratory diagnosis of TB.

Keywords: Guyana; multidrug resistance; tuberculosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2005.01521.x

Affiliations: 1: Department of Medical Microbiology and Immunology of Infection, Charité– University Medicine Berlin, Berlin, Germany 2: Faculty of Health Sciences, School of Medicine, University of Guyana, Georgetown, Guyana 3: Department of Biostatistics and Clinical Epidemiology, Charité– University Medicine Berlin, Berlin, Germany 4: Institute for Microbiology, Immunology, and Laboratory Medicine, Hospital Zehlendorf-Heckeshorn, Berlin, Germany 5: Ministry of Health Guyana, Georgetown, Guyana

Publication date: December 1, 2005

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