Free Content Multiple genotypes of the merozoite surface proteins 1 and 2 in Plasmodium falciparum infections in a hypoendemic area in Iran

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Abstract:

Summary

In Iran, malaria transmission mainly occurs in south-eastern regions through both Plasmodium falciparum and P. vivax. The genetic diversity of P. falciparum isolates was analysed in 108 patients attending the regional hospital in Chabahar District, using the molecular markers msp1 and msp2. Multiple genotypes were detected in 87% of patients and the mean numbers of msp1 and msp2 genotypes were 2.51 (95% CI: 2.29–2.73) and 2.61 (95% CI: 2.39–2.83) respectively. Various allelic types of msp1 and msp2 were found, with msp2 3D7/IC type detected in 94% of infections. Plasmodium falciparum infections in south-east Iran appear to have a higher genetic diversity than expected for an area of low transmission. A situation of higher transmission in this area may be emerging, possibly because of reduced efficacy of first-line treatments.

Keywords: Iran; Plasmodium falciparum; allelic family; genetic diversity; merozoite surface proteins 1 and 2; polymorphism

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2005.01477.x

Affiliations: 1: Malaria Research Group, Pasteur Institute of Iran, Tehran, Iran 2: Malaria Research Laboratory, Karolinska Institute, Stockholm, Sweden 3: Unité de Parasitologie Biomédicale, Institut Pasteur, Paris, France

Publication date: October 1, 2005

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