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Non-specific effects of vaccination on child survival? A prospective study in Senegal

Authors: Elguero, Eric1; Simondon, Kirsten B.1; Vaugelade, Jacques2; Marra, Adama3; Simondon, François1

Source: Tropical Medicine & International Health, Volume 10, Number 10, October 2005 , pp. 956-960(5)

Publisher: Wiley-Blackwell

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Abstract:

Summary Objectives 

Several studies have shown an association between vaccination and child mortality in developing countries. The present paper examines this issue using data from a Senegalese rural area which has been monitored from 1983 to the present. Methods 

We analysed two birth cohorts, comprising 7796 and 3573 persons who had received either BCG and DTP (diphtheria-tetanus-pertussis) simultaneously or neither of these vaccines, and who had been followed from birth to 2 years of age. The association between vaccinations and mortality was assessed by Cox proportional hazards model. Results 

Mortality ratios for recipients of the BCG/DTP combination were 0.59 (95% CI: 0.46–0.74) for the first cohort and 0.70 (0.50–0.97) for the second cohort. Mortality ratios for measles vaccine recipients were 0.98 (0.75–1.27) for the first cohort and 0.87 (0.57–1.30) for the second cohort. Conclusions 

The BCG/DTP combination was associated with a reduction in mortality whereas measles vaccination was not associated with mortality.

Keywords: Africa; Senegal; diphtheria-tetanus-pertussis; measles; mortality; vaccines

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2005.01479.x

Affiliations: 1: Epidémiologie et Prévention, Institut de Recherche pour le Développement (IRD), Montpellier, France 2: Laboratoire Population, Environnement et Développement, Institut de Recherche pour le Développement Montpellier, Montpellier, France 3: US Niakhar Espace de Recherche Intégrée sur la Santé des Populations, Institut de Recherche pour le Développement, Dakar, Senegal

Publication date: October 1, 2005

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