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Free Content Evaluation of non-specific effects of infant immunizations on early infant mortality in a southern Indian population

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Abstract:

Summary Objective 

The aim of this study was to assess the relationship between receipt of routine childhood immunizations and infant mortality before 6 months of age. Methods 

This was an observational study of 10 274 infants, in a randomized trial of vitamin A supplementation, who received the study dose and survived to at least 1 week of age. The primary outcome was mortality before 6 months of age, analysed in Cox regression models as a function of vaccine receipt and gender. Results 

Receipt of Bacille Calmette Guerin (BCG) or diphtheria, tetanus, polio (DTP) vaccine was associated with significant reductions of one-half to two-thirds of mortality hazards; among girls, those who received both BCG and DTP experienced higher mortality than those who received only one of the two vaccines (hazards ratio 2.4; 95% confidence interval 1.2–5.0). Conclusion 

The reduced mortality rate associated with receipt of BCG or DTP may be due to both biological and selection factors; the analyses regarding the combined effect of these vaccines and gender need to be replicated in other settings.

Keywords: BCG; DTP; infant mortality; vaccines; vitamin A

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2005.01434.x

Affiliations: 1: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 2: Aravind Centre for Women, Children and Community Health, Madurai, Tamil Nadu, India 3: Lions-Aravind Institute for Community Ophthalmology, Madurai, Tamil Nadu, India

Publication date: October 1, 2005

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