Authors: Julman R. Cermeño¹; Julmery J. Cermeño²; Isabel Hernández¹; Gerardo Godoy¹; July J. Cermeño³; Ismery Cabello²; Yida Orellán¹; Ytalia Blanco¹; Salvador Penna⁴

Source: Tropical Medicine & International Health, Volume 10, Number 3, March 2005 , pp. 216-219(4)

Publisher: Wiley-Blackwell

Abstract:

Summary Objective

To determine the prevalence of histoplasmosis and paracoccidiomycosis in Upata, a city in Bolívar state, Venezuela. Methods

Cutaneous tests on 397 volunteers, 204 with histoplasmine and 193 with paracoccidioidine. Epidemiological data were collected in a protocol sheet. Readings were performed at 24 and 48 h post-injection, by the same observer, and a positive reaction was defined as hardened papule of 5 mm or more. Results

Histoplasmine tests were positive in 19.6% and 34.0% at 24 and 48 h after antigens injection with a significant increase of reactivity (P = 0.0019). Paracoccidiodine tests were positive in 11.3% and 19.7% at 24 and 48 h respectively and this difference was also significant (P = 0.004). Risk factors which could explain these levels of reactivity could not be clearly identified. Cultures and animal inoculation from soil samples for fungus isolation were negative. Conclusions

Paracoccidioidomycoses and histoplasmosis are endemic in Upata.

Keywords: dermal reaction; histoplasmine; paracoccidioidine; Bolivar state; Venezuela

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2004.01376.x

Affiliations: 1: Departamento de Parasitología y Microbiología, Universidad de Oriente, Bolívar, Venezuela 2: Departamento de Medicina, Universidad de Oriente, Bolívar, Venezuela 3: Distrito Sanitario II Sección de Epidemiología, San Félix, Venezuela 4: Departamento de Ciencias Fisiológicas Universidad de Oriente, Bolívar, Venezuela

Publication date: 2005-03-01

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