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Free Content Histoplasmine and paracoccidiodine epidemiological study in Upata, Bolívar state, Venezuela

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Summary Objective 

To determine the prevalence of histoplasmosis and paracoccidiomycosis in Upata, a city in Bolívar state, Venezuela. Methods 

Cutaneous tests on 397 volunteers, 204 with histoplasmine and 193 with paracoccidioidine. Epidemiological data were collected in a protocol sheet. Readings were performed at 24 and 48 h post-injection, by the same observer, and a positive reaction was defined as hardened papule of 5 mm or more. Results 

Histoplasmine tests were positive in 19.6% and 34.0% at 24 and 48 h after antigens injection with a significant increase of reactivity (P = 0.0019). Paracoccidiodine tests were positive in 11.3% and 19.7% at 24 and 48 h respectively and this difference was also significant (P = 0.004). Risk factors which could explain these levels of reactivity could not be clearly identified. Cultures and animal inoculation from soil samples for fungus isolation were negative. Conclusions 

Paracoccidioidomycoses and histoplasmosis are endemic in Upata.

Keywords: Bolivar state; Venezuela; dermal reaction; histoplasmine; paracoccidioidine

Document Type: Research Article


Affiliations: 1: Departamento de Parasitología y Microbiología, Universidad de Oriente, Bolívar, Venezuela 2: Departamento de Medicina, Universidad de Oriente, Bolívar, Venezuela 3: Distrito Sanitario II Sección de Epidemiología, San Félix, Venezuela 4: Departamento de Ciencias Fisiológicas Universidad de Oriente, Bolívar, Venezuela

Publication date: 2005-03-01

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