Free Content Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria

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Abstract:

Summary

In an unmatched case–control study of 63 non-immune European patients with uncomplicated (n = 52) and complicated (n = 11) falciparum malaria, serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (H-FABP), myoglobin, troponin T and creatin kinase-muscle brain were compared. Elevated levels of NT-proBNP and H-FABP indicated myocardial impairment in complicated but not in uncomplicated falciparum malaria. The clinical impact of these findings remains to be evaluated. The pathophysiology of cardiac impairment in complicated falciparum malaria warrants further investigation.

Keywords: N-terminal pro-brain natriuretic peptide; cardiac impairment; heart-type fatty acid-binding protein; malaria; myocard; troponin

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2004.01303.x

Affiliations: 1: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany 2: Department of Tropical Medicine and Infectious Diseases, University of Rostock Medical School, Rostock, Germany

Publication date: October 1, 2004

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