High prevalence of ectopic kidney in Coast Province, Kenya
To establish the prevalence of congenital urinary tract abnormalities in a full population-based ultrasound survey of an area of coastal Kenya. Methods
Ultrasound examination of 3118 residents of 912 households, including allavailable subjects over 2 years of age, residing in five contiguous rural villages 50 km south of Mombasa. Results
Survey findings indicated simple renal ectopia in 11 of 3118 subjects (0.35%) and renal agenesis in three (0.096%). No cases of horseshoe kidney or complex urinary anomaly were detected, and no cases of multiple congenital anomaly were found. Ectopia cases were evenly distributed between men and women, and across the five study villages. None of the individuals affected by renal ectopia were closely related (i.e. <5th-degree relations). Conclusion
There is an unusually high prevalence of ectopia among unrelated subjects in this area. In this setting, the findings suggest either a common exposure to teratogenetic factors, or a hereditary condition with variable penetrance, where more severely affected individuals are not observed because of foetal/infant mortality.
Document Type: Research Article
Affiliations: 1: Formerly Department of Radiology, Ministry of Health, Nairobi, Kenya 2: Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, OH, USA 3: Kenya Medical Research Institute, Nairobi, Kenya 4: Department of Radiology, Kenyatta National Hospital, Nairobi, Kenya 5: Division of Vector Borne Diseases, Ministry of Health, Nairobi, Kenya
Publication date: 2004-05-01