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Free Content Tuberculous meningitis and miliary tuberculosis in young children

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Abstract:

Summary Objectives 

To document the clinical and diagnostic features of tuberculous meningitis (TBM) in young children with and without concomitant miliary tuberculosis (TB). Methods 

A retrospective comparative study. Results 

Of 104 children with TBM, 32 (31%), median age 17.0 months, had a miliary appearance on chest radiograph; 72 (69%), median age 30.5 months, had TBM only (P = 0.04). Mediastinal adenopathy was noted in 27 (84%) of the children with miliary TB and 33 (46%) of those with TBM only (P = 0.0005). The mean cerebrospinal fluid (CSF) lymphocyte and polymorphonuclear counts of all children (no significant differences between groups) were 137 × 106/l and 38 × 106/l and the mean protein and glucose concentrations were 1.45 g/l and 0.72 mmol/l, respectively. Polymorphonuclear leukocytes were predominant in the CSF of 17% of children, in 16% the CSF glucose was >2.2 mmol/l and in 26% the CSF protein was <0.8 g/l. On Mantoux testing 37 (65%) of 57 children with TBM only and 12 (48%) of 25 children with TBM and miliary TB had an induration of ≥10 mm (P = 0.23). Ten children (10%) died, five (7%) who had TBM only and five (16%) who had TBM and miliary TB. Conclusion 

Children with TBM and miliary TB were younger and more likely to have mediastinal adenopathy on chest radiography than those with TBM only. Diagnostic features and investigations in both groups may be misleading at times.

Keywords: meningitis; miliary tuberculosis; tuberculosis

Document Type: Research Article

DOI: https://doi.org/10.1046/j.1365-3156.2003.01185.x

Affiliations: 1:  Utrecht University Medical Center, Utrecht, The Netherlands 2:  Wilhelmina Children's Hospital, Utrecht, The Netherlands 3:  Department of Paediatrics and Child Health, Tygerberg Children's Hospital and the University of Stellenbosch, Tygerberg, South Africa

Publication date: 2004-02-01

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