Skip to main content

Free Content Efficacy of mefloquine and mefloquine–artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon region of Bolivia

Download Article:

You have access to the full text article on a website external to ingentaconnect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Abstract:

Summary

We assessed the efficacy of mefloquine monotherapy and mefloquine–artesunate (MQ–AS) combination therapy for the treatment of Plasmodium falciparum malaria at four sites in the Bolivian Amazon region. Patients with uncomplicated P. falciparum infections between 5 and 60 years of age were randomly assigned to be treated with either MQ (15 mg/kg in a single oral dose) or MQ (15 mg/kg) plus AS (4 mg/kg daily for 3 days). A total of 143 patients were enrolled and followed for 28 days. None of the 73 patients who received MQ alone or the 70 patients who received MQ–AS combination therapy had recurrences of parasitaemia during the 28-day follow-up period. Asexual parasite densities fell significantly more rapidly and the proportion of patients with gametocytes was significantly lower on days 7–28 in patients treated with MQ–AS than in those treated with MQ alone. All patients tolerated the medications well. After this study, the Bolivian Ministry of Public Health changed its treatment policy for uncomplicated P. falciparum malaria in the Amazon region to combination therapy with MQ–AS to slow or prevent the development of resistance.

Keywords: Bolivia; Plasmodium falciparum; antimalarial drug resistance; artesunate; mefloquine

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-3156.2003.01184.x

Affiliations: 1:  Programa Nacional de Vigilancia y Control de la Malaria, Ministerio de Salud Pública y Previsión Social, La Paz, Bolivia 2:  Instituto Nacional de Salud, Lima, Peru 3:  Centers for Disease Control and Prevention, US Naval Medical Research Center Detachment, Lima, Peru

Publication date: February 1, 2004

bsc/tmih/2004/00000009/00000002/art00005
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more