Transmission of Helicobacter pylori infection in families of preschool-aged children from Minas Gerais, Brazil
We evaluated the role of the family in the transmission of Helicobacter pylori infection in preschool-aged children from a rural district in the State of Minas Gerais, Brazil. Sixty-six families (66 index children, 63 mothers, 60 fathers and 134 siblings), defined as at least one parent living in the same household with at least one offspring up to 8 years old, were studied. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression controlling for age, gender, number of children in household and H. pylori status of the father, mother and siblings. The prevalence of the infection was 69.7% (469 of 673) and it increased with age (P < 0.001). Positive mothers were a strong and independent risk factor for infection (OR 22.70; 95% CI 2.31–223.21). Positive siblings were also positively associated with infection (OR 1.81; 95% CI 1.01–3.30).
Document Type: Research Article
Affiliations: 1: Laboratory of Research in Bacteriology, Faculdade de Medicina, UFMG, Belo Horizonte, Brazil 2: Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA 3: Escola de Enfermagem, UFMG, Belo Horizonte, Brazil 4: Laboratório de Imunologia Celular e Molecular, Centro de Pesquisa Renê Rachou/FIOCRUZ, Belo Horizonte, Brazil
Publication date: 2003-11-01