Free Content Rapid diagnostic testing for malaria

You have access to the full text article on a website external to ingentaconnect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Download Article:

Abstract:

Summary

Malaria rapid diagnostic devices (MRDD) have been developed with the hope that they would offer accurate, reliable, rapid, cheap and easily available alternatives to traditional methods of malaria diagnosis. The results from early malaria rapid diagnostic studies were quite promising, especially for detecting Plasmodium falciparum at densities of more than 100–500 parasites/μl. Despite the introduction of these devices over a decade ago, only a few target antigens have been introduced. Of greater concern, these devices have shown limitations in sensitivity, ability to differentiate species and robustness under field conditions in the tropics. Recent trials have revealed wide variability in sensitivity both within and between products. We review the recent trials assessing MRDD use for the diagnosis of P. falciparum and non-P. falciparum infections in endemic and non-endemic countries and describe the various aspects of these devices which need further improvement. High quality, accurate, rapid and affordable diagnostic tools are urgently needed now that new antimalarial regimens, characterized by higher cost and increased toxicity, have been introduced more widely in response to emerging multi-drug resistance.

Keywords: diagnosis; malaria; rapid test

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-3156.2003.01115.x

Affiliations: 1: Infectious Diseases Service, Brooke Army Medical Center, San Antonio, TX, USA 2: Malaria, other Vector-borne and Parasitic Diseases (MVP), World Health Organization Western Pacific Region (WHO/WPRO), Manila, The Philippines 3: Walter Reed Army Institute of Research, Silver Spring, MD, USA 4: Parasitic Diseases Program, U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia

Publication date: October 1, 2003

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more