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Free Content Absence of the kdr mutation in the molecular ‘M’ form suggests different pyrethroid resistance mechanisms in the malaria vector mosquito Anopheles gambiae s.s.

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Abstract:

Summary

Field tests conducted on adult Anopheles mosquitoes using standard WHO procedures, diagnostic kits and test papers in south-western Nigeria showed pyrethroid (deltamethrin and permethrin) resistance in adult populations of Anopheles gambiae sensu stricto. The knock-down resistance (kdr) mutation involved in pyrethroid resistance was only found in the molecular S form of An. gambiae s.s. even in area where both molecular M and S forms occurred in sympatry. The absence of the kdr mutation in the M form suggests an additional pyrethroid resistance mechanism in An. gambiae s.s.

Keywords: Anopheles gambiae; molecular forms; pyrethroid kdr resistance

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-3156.2003.01034.x

Affiliations: Medical Entomology, Department of Clinical Microbiology and Infectious Diseases, School of Pathology of the National Health Laboratory Services and the University of the Witwatersrand, Johannesburg, South Africa

Publication date: May 1, 2003

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