Skip to main content

Geographic differences in hepatosplenic complications of schistosomiasis mansoni and explanatory factors of morbidity

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

In a study in three neighbouring villages of southern Madagascar, where Schistosoma mansoni is hyperendemic, ultrasound examination using the Niamey protocol showed marked differences in the burden of disease from one village to another. Hepatosplenic schistosomiasis was more frequent in the village with the highest geometric mean egg counts and the earliest onset of infections, demonstrating that the morbidity induced by S. mansoni may vary greatly within a given area. True representativeness of study populations, a keystone of epidemiological studies, is mandatory to obtain a clear picture of a wide area. Ultrasound examinations in a small number of villages, or even a single one, may be a questionable approach. Using logistic regression analysis, the explanatory variables found to be significantly associated with a risk of severe hepatosplenic disease in our study were sex, age, village of residence and S. mansoni egg counts. On the other hand, a concurrent infection with an intestinal helminth seems to reduce the risk of severe hepatosplenic disease. Further studies should assess the role and possible impact of intestinal helminths on S. mansoni associated-morbidity.

Keywords: Madagascar; Schistosoma mansoni; epidemiology; intestinal helminths; morbidity; ultrasonography

Document Type: Research Article

DOI: https://doi.org/10.1046/j.1365-3156.2001.00781.x

Affiliations: 1: Institut Pasteur, Antananarivo, Madagascar, France 2: Direction de la Lutte contre les Maladies Transmissibles, Ministère de la Santé, Antananarivo, Madagascar, France

Publication date: 2001-09-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more