Skip to main content

Latex based, rapid and easy assay for human leptospirosis in a single test format

Buy Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.


Leptospirosis is an often severe disease which requires prompt treatment. Laboratory testing is required to reach a valid diagnosis. An agglutination assay for the detection of Leptospira-specific antibodies consisting of individually wrapped agglutination cards containing a stable, dried detection reagent is evaluated. The assay is simply performed by suspending the dried reagent with a drop of serum. The result is obtained within 30 s. The sensitivity of the assay varied with the stage of the disease and was 72.3% for samples collected during the first 10 days of the illness and 88.2% for samples collected at a later stage. The specificity was 93.9% and 89.8%, respectively. These characteristics make the test ideal for use in areas where the disease is common and where laboratory support is not routinely available.

Keywords: ELISA; latex agglutination assay; leptospirosis; microscopic agglutination assay; serodiagnosis

Document Type: Research Article

Affiliations: 1: Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands 2: Department of Dermatology, Academic Hospital, Paramaribo, Surinam 3: Malankara Orthodox Syrian Church Medical Mission Hospital, Kolenchery, India 4: Department of Medicine, Dr Kariadi Hospital/Diponegoro University, Semarang, Indonesia 5: Department of Medicine, Victoria Hospital, the Seychelles 6: Epidemiology Branch, Department of Health, Honolulu, Hawaii, USA 7: Department of Internal Medicine, Academic Hospital, Paramaribo, Surinam

Publication date: 2001-02-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more