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Free Content Short communication: Paracheck-Pf®: a new, inexpensive and reliable rapid test for P. falciparum malaria

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Abstract:

We compared the performance of Paracheck-Pf®, a new and cheap rapid malaria test, with ICT-Pf/Pv® and microscopy in two malaria surveys in Thai villages on the Thai-Burmese border. The specificity, sensitivity, predictive positive and negative values of the Paracheck-Pf® and ICT-Pf® tests were calculated taking microscopy results as the gold standard. The 294 ICT-Pf/Pv tests resulted in two invalid (no control line) and 11 doubtful results. Both the ICT-Pf/Pv® and Paracheck-Pf® tests reliably detected P. falciparum infections. However, Paracheck-Pf® failed to detect three P. falciparum cases and likewise, ICT-Pf/Pv® failed to detect the same three cases and an additional four cases. These seven cases were detected by microscopy and had a parasitaemia under 150 parasites/l. At a cost of c. US $1.00, the Paracheck-Pf® test, based on the detection of the P. falciparum specific HRP-2 protein, is a reliable, easy to use and affordable tool for the diagnosis of P. falciparum malaria.

Keywords: HRP-2; Plasmodium falciparum; malaria diagnosis; rapid tests

Document Type: Short Communication

Affiliations: 1: Shoklo Malaria Research Unit, Mae Sod, Thailand 2: Programme for Appropriate Technology in Health, Ottawa, Canada

Publication date: February 1, 2001

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