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Specificity of circulating antigen detection for schistosomiasis mansoni in Senegal and Burundi

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The specificity of schistosome circulating antigen detection was determined in negative individuals from two S. mansoni- endemic countries, Senegal and Burundi, and compared with results from Dutch control individuals. A nearly absolute specificity was achieved for circulating anodic antigen (CAA) detection in serum, irrespective of the target population or sample pretreatment method. Circulating cathodic antigen (CCA) detection in serum and urine resulted in a lower specificity than serum CAA detection. Apparent large differences in specificity of CCA detection between countries were mainly due to pretreatment methods. Apparently, the alkaline/heating pretreatment method is not as effective as trichloroacetic acid (TCA) -pretreatment in removing (certain) interfering components, which may vary between populations. In view of the development of the urine CCA assay into a noninvasive screening test, a slightly lower specificity may still be acceptable. For precise epidemiological analyses the highly specific serum CAA assay remains the method of choice.

Keywords: Schistosoma mansoni; circulating anodic antigen (CAA); circulating cathodic antigen (CCA); endemic countries; pretreatment; specificity

Document Type: Research Article


Affiliations: 1: WHO, Parasitic Disease and Vector Control, Communicable Diseases Control, Prevention and Eradication, Geneva, Switzerland 2: Programme de Lutte contre les Maladies Transmissibles et Carentielles, Ministère de la Santé Publique du Burundi, Bujumbura, Burundi 3: Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands 4: Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium

Publication date: August 1, 2000

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