Skip to main content

Inhibition of glutathione synthesis as a chemotherapeutic strategy for leishmaniasis

Buy Article:

$51.00 plus tax (Refund Policy)



This study focuses on the use of buthionine sulphoximine (BSO), a γ-glutamylcysteine synthetase inhibitor, on Leishmania donovani growth. The effect of BSO on amastigote multiplication within macrophages showed that 5┬ámmBSO decreased infectivity by about 50% and the mean number of amastigotes per 100 infected macrophages by 21%. The mechanism may be that BSO resulted in enhanced nitric oxide (NO) levels within macrophages, probably due to inhibition of GSH content since GSH (10┬ámm) given after BSO treatment led to a decrease in NO compared to macrophages treated with BSO alone which were preexposed to the Leishmania surface molecule lipophosphoglycan.

Keywords: Leishmania donovani; glutathione; l-buthionine sulphoximine (BSO); nitric oxide

Document Type: Research Article


Affiliations: School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

Publication date: 2000-06-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more