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Glucose-6-phosphate dehydrogenase deficiency in northern Vietnam

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency was evaluated in 1676 schoolboys in northern Vietnam. The trait was nearly absent in boys of the Kinh (0.5%) and the Mong (0.7%) ethnic groups that traditionally have lived outside malaria transmission areas. Prevalences among ethnic groups living in the foothills, the breeding area of the main malaria vector Anopheles minimus, ranged from 9.7% to 31%. These findings support the hypothesis of a selective advantage of the trait in Plasmodium falciparum-endemic areas.

Keywords: G6PD deficiency; Vietnam; malaria transmission; selective advantage

Document Type: Research Article


Affiliations: 1: Belgian Administration for Development Cooperation, Brussels, Belgium 2: National Institute of Malariology, Parasitology and Entomology, Hanoi, Vietnam 3: Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium

Publication date: 2000-03-01

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