Skip to main content

Treating neurocysticercosis medically: a systematic review of randomized, controlled trials

Buy Article:

$51.00 plus tax (Refund Policy)

Summary

objective To summarize the evidence from randomized controlled trials on the effects of cysticidal therapy used for treating human cysticercosis.

methods Published and unpublished studies in any language identified through MEDLINE (1966 – June 1999) specialized databases, abstracts, proceedings and contact with experts were analysed. Those which compared, using randomized or quasi-randomized methods, any cysticidal drug with placebo or symptomatic therapy were entered in the study. Data were extracted independently by two reviewers and trial quality assessed. Meta-analysis using fixed effects models calculated provided there was no significant heterogeneity, expressed as relative risk.

results Four trials met the inclusion criteria, treating intraparenchymatous neurocysticercosis with either albendazole or praziquantel compared to placebo or no treatment. In the two trials reporting clinical outcomes, treatment was not associated with a reduction in the risk of seizures, although numbers were small (RR 0.95, 95% CI 0.59–1.51). Four trials reported radiological outcomes, and cysticidal treatment was associated with a lower risk of cyst persistence of scans taken within six months of start of treatment (RR 0.83, 95% CI 0.70–0.99). Subsidiary analysis assuming different outcomes in patients lost to follow-up did not alter the findings of the main analysis.

conclusions There is insufficient evidence to determine whether cysticidal therapy is of any clinical benefit to patients with neurocysticercosis. The review does not exclude the possibility that more patients remain seizure-free when treated with cysticidal drugs. Further testing through placebo-controlled trials is required.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: cysticercosis; drug therapy; meta-analysis; neurocysticercosis; treatment outcome

Document Type: Research Article

Affiliations: 1: Ministry of Health, Santiago, Chile 2: Neurosciences Trials Unit, University of Edinburgh, UK 3: Department of Neurology, All India Institute of Medical Research, New Delhi, India 4: Liverpool School of Tropical Medicine, Liverpool, UK

Publication date: 1999-11-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more