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Circulating antibodies and antigens correlate with egg counts in human fascioliasis

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We explored the relationships between specific IgG antibody levels and circulating E/S antigen to intensity of Fasciola infection in the human host. Twenty patients with patent infection and six healthy individuals were enrolled in the study. Intensity of infection was determined by repeated egg counts in stools, while IgG antibodies against adult Fasciola gigantica somatic FI, FII and against E/S antigens were measured as ELISA O.D. readings. The level of circulating E/S antigens was determined by IELISA. Positivity as well as levels of antibodies and antigen correlated with infection intensity. These findings may disclose in the future a relation between morbidity in the acute phase and worm load.
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Keywords: antibodies; circulating antigens; egg counts; human fascioliasis

Document Type: Research Article

Affiliations: 1: Department of Parasitology, Medical Research Institute, University of Alexandria, Egypt 2: Department of Tropical Health, High Institute of Public Health, University of Alexandria, Egypt 3: Department of Medical Statistics, Medical Research Institute, University of Alexandria, Egypt

Publication date: 1999-10-01

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