In vitro antiplasmodial activity of Central American medicinal plants

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Abstract:

Summary

The in vitro antiplasmodial activities of 14 plant species traditionally used in Central America for the treatment of malaria or fever were evaluated. Lipophilic extracts of Piper hispidum, Siparuna andina, S. pauciflora, S. tonduziana, and Xylopia cf. frutescens, proved to be active against both a chloroquine-sensitive and a resistant strain of Plasmodium falciparum. IC50 values ranged between 3.0 μg/ml and 21.9 μg/ml; however, moderate cytotoxicity of active extracts was observed. Bioactivity-guided fractionation of Piper hispidum yielded 2′,4,6′-trihydroxy-4′-methoxydihydrochalcone (asebogenin) as an active compound.

Keywords: Piper hispidum; Plasmodium falciparum; Siparuna andina; Siparuna pauciflora; Siparuna tonduziana; Xylopia cf. frutescens; antimalarial activity; plant extracts

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-3156.1999.00456.x

Affiliations: 1: Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Berlin, Germany 2: Institut für Tropenmedizin und Medizinische Fakultät Charité der Humboldt Universität zu Berlin, Berlin, Germany 3: Centro de Investigaciones Farmacognosticas de la Flora Panameña (CIFLORPAN), Universidad de Panama, Panamá, Republica de Panama

Publication date: September 1, 1999

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