The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

SummaryTo examine a possible relationship between the immune response and haematological recovery after acute falciparum malaria, we followed peripheral blood eosinophil counts and haemoglobin concentrations for 4 weeks after starting effective treatment in 70 adult Thai patients. Eosinophils are induced by Th-2 cytokines as well as other stimuli. Eosinophil counts were elevated in only 8 (11%) of the subjects at presentation, but were increased in 65 (93%) by day 7. Eosinophil counts then decreased markedly by day 14, followed by a second increase until day 28. A significant positive correlation was found between peak eosinophil counts on day 7 and the haemoglobin concentration on day 28, both in 16 subjects without stool parasites (= 0.65, = 0.006) and in 54 patients with stool parasites (= 0.32; = 0.0019). These results suggest that a robust eosinophilic response shortly after completing antimalarial therapy predicts a good recovery from malaria-associated anaemia.

Keywords: Plasmodium falciparum malaria; Th-2 immune response; anaemia; eosinophilia; eosinophils; haemoglobin concentration

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-3156.1999.00426.x

Affiliations: 1: Department of Medicine, The George Washington University Medical Center, Washington DC, USA 2: Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 3: Department of Medicine, University Hospital, Innsbruck, Austria 4: Division of Pediatric Hematology, Columbia College of Physicians and Surgeons, New York, USA

Publication date: July 1, 1999

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more