Seroprevalence of viral hepatitis in Tanzanian adults
Abstract:In a cross-sectional study in Dar es Salaam, Tanzania, we determined the seroprevalence of markers for hepatitis A, B, C and E viruses and examined associated risk markers. Among 403 healthy adults, the seroprevalence of antibodies to hepatitis A virus was 99.0% (95% confidence interval: 97.5–99.7). Prior exposure to hepatitis C and E viruses was rare (hepatitis C: 0.7% (0.2–2.1); hepatitis E: 0.2% (< 0.1–1.4)). The prevalence of all markers of hepatitis B was 70.7% (66.0–75.1). Hepatitis B surface antigen was identified in 6.0% (3.9–8.7) of subjects. Independent predictors of hepatitis B infection identified by logistic regression included older age, male gender, Muslim religion and type of abode. Given the high prevalence of hepatitis B and the low prevalence of hepatitis C, the majority of chronic viral hepatitis is likely to be associated with hepatitis B. Control efforts should focus primarily on hepatitis B.
Document Type: Research Article
Affiliations: 1: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 2: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 3: Kilimanjaro Christian Medical Center, Moshi, Tanzania 4: Department of Biology, Campbell University, Buies Creek, NC, USA 5: Experimental Biology Research, Abbott Laboratories, North Chicago, IL, USA 6: Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC, USA
Publication date: September 1, 1998