Skip to main content

Malaria anticircumsporozoite antibodies in dutch soldiers returning from sub-saharan africa

Buy Article:

$51.00 plus tax (Refund Policy)


One hundred and twenty-five Dutch servicemen returning from central Africa after a short deployment were enrolled in a study aimed at assessing the effectiveness of malaria prevention measures. None of the persons developed an episode of clinically overt malaria during or after deployment, and no antibodies against blood stages of Plasmodium falciparum could be found. However, antibodies against the circumsporozoite protein (CS) of P. falciparum were demonstrable in 14 persons (11.2% of the study population) by an ELISA test using the recombinant CS-antigen R32tet32, while one person only was positive in an IFA test based on schizonts of P. fieldi as antigen. We concluded that the anti-CS-positive servicemen were probably bitten by mosquitoes carrying P. falciparum parasites while the IFA-positive person was possibly infected by P. vivax, P. ovale or P. malariae parasites. There was no significant association between the different antimalaria preventive measures and the development of anti-CS antibodies. Therefore mefloquine prophylaxis as the single most widely used preventive measure in this group of servicemen was possibly a major contributing factor in averting development of overt malaria.

Keywords: P. falciparum; P. fieldi; P. malariae; P. ovale; P. vivax; antibodies; circumsporozoite protein

Document Type: Research Article


Affiliations: 1: Infectious Diseases Control Unit, Occupational Health and Safety Services, Royal Netherlands Army, Utrecht, 2: Office of the Surgeon General, Royal Netherlands Army, The Hague, 3: Department of Parasitology, Academic Hospital St. Radboud, University of Nijmegen, The Netherlands, 4: Department of Epidemiology and Public Health, University of Wageningen, The Netherlands.

Publication date: January 1, 1998


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more