Skip to main content

Evaluation of a commercial immunodiagnostic kit incorporating lipoarabinomannan in the serodiagnosis of pulmonary tuberculosis in Ghana

Buy Article:

$43.00 plus tax (Refund Policy)

We evaluated ‘Mycodot’, a commercially marketed immunodiagnostic test for tuberculosis which detects antibodies to lipoarabinomannan antigen. Serum was tested from 52 patients with newly diagnosed smear-positive pulmonary tuberculosis, of whom 20 were HIV-positive and 32 HIV-negative. Control sera were taken from 40 patients of whom 20 had acute non-tuberculous lobar pneumonia and 20 patients had no respiratory disease. The test was found to have a very high specificity of 97.5% (95%Cl:92.5–100%). However, the sensitivity in HIV-negative patients was 56% (95%Cl:39–73%), and was substantially lower at 25% (95%Cl:6–44%) in HIV-positive patients. In conclusion: ‘Mycodot’ was found to be a highly specific and easily performed assay. However, the poor sensitivity, especially in HIV- infected patients, renders it unlikely to be useful either as a primary or adjunctive diagnostic test for tuberculosis, particularly in countries with a high prevalence of HIV. A larger trial of this assay in Ghana was not deemed necessary.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: HIV; Tuberculosis; diagnosis; lipoarabinomannan; serology

Document Type: Original Article

Affiliations: 1: Department of Medicine, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana, 2: Department of Microbiology, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana, 3: National Tuberculosis Control Programme, Ministy of Health, Accra, Ghana

Publication date: 1997-10-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more