Skip to main content

The pharmacokinetics of a single dose of artemisinin in subjects with liver cirrhosis

Buy Article:

$43.00 plus tax (Refund Policy)

Artemisinin is mainly eliminated by hepatic transformation. To investigate whether the clearance of artemisinin in patients with liver cirrhosis is different from healthy volunteers, a pharmacokinetic study was performed in male Vietnamese patients with Child B cirrhosis of the liver who received 500 mg of artemisinin orally. The results were compared to those found in a previous study in healthy subjects. The mean (± SD) area under the concentration time curve was 2365 (± 1761)h ng/ml; the mean (± SD) clearance, 382 (± 303)L/h. The elimination half life was 4 (± 1.3)h extimated by log-linear regression and 2.4 ± 0.9h estimated by non-linear regression using a one-compartment first order elimination model. The mean (± SD) absorption time was 1.55 (± 0.8)h. These results were not different from the results of healthy subjects and show that liver disease has no effect on the availability and clearance of oral artemisinin, indicating that artemisinin has an intermediate hepatic extraction ratio and that there is no significant first pass effect.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: artemisinin; liver cirrhosis; pharmacokinetics

Document Type: Original Article

Affiliations: 1: Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, The Netherlands, 2: Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam, 3: Institute of Malariology, Parasitology and Entomology, Hanoi, Vietnam, 4: Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Centre, University of Amsterdam, The Netherlands

Publication date: 01 October 1997

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more