Skip to main content

Anti-malarial drug resistance, malnutrition and socio-economic status

Buy Article:

$43.00 plus tax (Refund Policy)

To investigate the relationship between nutritional status and resistance to chloroquine treatment, we designed a nested case-control study prospective with respect to the outcome of Plasmodium falciparum-infected school children aged 5–14 years from Honiara, Solomon Islands. 38 chloroquine-resistant cases were compared with treatment-susceptible controls with respect to current nutritional status, behavioural characteristics, medical and demographic data. The overall prevalence of moderate malnutrition was 28%. The incidence rate of chloroquine resistance was 23%. Malnourished children were generally at higher risk for treatment failure than well-nourished ones (OR: 3.6; 95%CI: 1.6–8.4; P= 0.001). This effect was modified by socio-economic status. Stratified analysis by logistic regression resulted in an eightfold risk of resistance for malnourished children in the higher socio-economic category (OR:8.1; 95%CI: 2.4–27.9; P= 0.0001). In children from the lower socio-economic group, the effect of malnutrition was not significant (OR:1.5; 95%CI:0.4–5.6). Socio-economic differences may affect the immune status. The treatment response in children of lower socio-economic status, which are more exposed to malaria, may therefore be less affected by malnutrition.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Plasmodium falciparum; malnutrition; resistance; socio-economic status

Document Type: Original Article

Affiliations: 1: Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany, 2: Solomon Island Ministry of Health, 3: Army Malaria Research Unit, Ingleburn, NSW, Australia

Publication date: 1997-08-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more