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Protective effect of Trypanosoma rangeli against infections with a highly virulent strain of Trypanosoma cruzi

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Abstract:

We investigated the protective effect of Trypanosoma rangeli against infection with Trypanosoma cruzi in animal models of various ages and with different doses of inoculum. The age of the mice and the dose of parasites determined the course of the infection. When T. cruzi was inoculated into mice after challenge with T. rangeli, parasitaemia was more controlled, mortality decreased and histopathology showed lower inflammatory infiltration and pseudocysts. This study proposes a new murine model of the protective effect of recombinant proteins of T. rangeli for possible application in the vaccines field.

Keywords: Chagas' disease; T. cruzi; Trypanosoma rangeli; protective effect; vaccine

Document Type: Original Article

DOI: http://dx.doi.org/10.1046/j.1365-3156.1997.d01-297.x

Affiliations: 1: Chili University School of Medicine, Spain, 2: National Institute of Health, Colombia, 3: Parasitology and Tropical Medicine Unit, Department of Preventive Medicine and Public Health, Autonomous University of Madrid, Spain, 4: Pathology Department, Hospital La Paz, Madrid, Spain

Publication date: May 1, 1997

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