Skip to main content

Susceptibility of Ugandan Trypanosoma brucei rhodesiense isolated from man and animal reservoirs to diminazene, isometamidium and melarsoprol

Buy Article:

$43.00 plus tax (Refund Policy)

Thirty‐six Trypanosoma brucei spp. stocks isolated from man and domestic animals in south‐east Uganda were studied for susceptibility to diminazene, isometamidium and melarsoprol in vitro. All stocks were susceptible to melarsoprol. One T. b. rhodesiense stock isolated from a sleeping sickness patient showed reduced susceptibility to the veterinary drugs diminazene and isometamidium. More than 100 ng/ml diminazene or 0.78 ng/ml isometamidium were required to eliminate that stock during 10 days drug exposure. In contrast, the remaining stocks were eliminated by 0.8–6.3 ng/ml diminazene and 0.01–0.20 ng/ml isometamidium. Clones derived from the resistant T. b. rhodesiense stock showed reduced susceptibility to isometamidium and diminazene comparable to the parental population. Control of sleeping sickness by treatment of the animal reservoir could, therefore, face serious problems since drug‐resistant stocks as reported here would most likely not be eliminated by recommended doses of diminazene and isometamidium.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: T. b. rhodesiense; Trypanosoma brucei spp; animal reservoir; drug resistance; drug susceptibility

Document Type: Original Article

Affiliations: 1: Livestock Health Research Institute, Tororo, Uganda, 2: Swiss Tropical Institute, Basel, Switzerland, 3: Faculty of Veterinary Medicine, Makerere University, Kampala, Uganda

Publication date: 01 January 1997

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more