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Membrane characterization of amastigote-like forms of Leishmania donovani

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Abstract:

During in vitro transformation, Leishmania donovani promastigotes converted into amastigote-like forms and underwent several changes in membrane parameters. They exhibited significantly increased microviscosity comparable to true amastigotes. Activities of several functionally important membrane bound enzymes were also altered, thereby indicating a change in their orientation. Peanut agglutinin was found to be specific for agglutination of stationary phase promastigotes whereas wheat-germ agglutinin was specific for the amastigote-like forms as well as for pure amastigotes, implying the presence of specific glycoconjugates on the parasite surface.

Keywords: Leishmania donovani; amastigote-like forms; lectin binding; microviscosity

Document Type: Research Article

Affiliations: 1: Division of Biochemistry, Central Drug Research Institute, Lucknow, India 2: Division of Developmental Toxicology, Industrial Toxicology Research Centre, Lucknow, India

Publication date: 1996-08-01

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