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Ultrasonographic assessment of the adulticidal efficacy of repeat high-dose ivermectin in bancroftian filariasis

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Abstract:

Since diethylcarbamazine, the drug recommended for treatment of lymphatic filariasis, seems only partially effective against the adult worm, intense interest persists in identifying a macrofilaricidal drug for this infection. To evaluate directly in vivo the macrofilaricidal activity of repeat high-dose ivermectin, 15 men who had living adult Wuchereria bancrofti detected in the scrotal area by ultrasound were treated with 400 mug/kg of ivermectin at 2-week intervals for 6 months (total dose, 4.8 mg/kg). Serial ultrasound examinations were performed before, during, and for 6 months after treatment. Profound suppression of microfilaraemia followed the first dose of ivermectin, but movements characteristic of the adult worm on ultrasound remained unchanged both in location and pattern. Even when given in total doses of 4.8 mg/kg, ivermectin appears to have no observable activity against adult W. bancrofti, although its ability to suppress microfilaraemia makes it potentially useful for the control of lymphatic filariasis.

Keywords: Wuchereria bancrofti; filariasis; ivermectin; ultrasound

Document Type: Research Article

Affiliations: 1: Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhaes-FIOCRUZ, Recife, Brazil 2: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 3: Hospital das Clinicas, Universidade Federal de Pernambuco, Recife, Brazil 4: Mediax, Memorial Imagem e Diagnostico, Recife, Brazil

Publication date: August 1, 1996

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