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Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: the use of melarsoprol combined with the 5‐nitroimidazole, megazol

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Abstract:

Megazol, one of a number of related 5‐nitroimidazoles, can be dissolved in dimethylsulphoxide and the solution can be converted into a gel by the addition of hydroxypropylcellulose which facilitates the ease and accuracy of administration. This megazol gel, when used in combination with melarsoprol (3.6%) in propylene glycol gel, will cure experimental CNS‐trypanosomiasis in mice. A single application of 0.1 ml of melarsoprol (3.6%) gel plus 0.1 ml of either 8 or 16 mg/ml megazol gel successfully treated experimental CNS‐trypanosomiasis while two consecutive days' treatment with 0.05 ml melarsoprol and 0.1 ml of 16 or 32 mg/ml megazol gels also produced satisfactory cures.

Keywords: 5‐nitroimidazoles; CNS‐trypanosomiasis; megazol; melarsoprol

Document Type: Original Article

DOI: https://doi.org/10.1046/j.1365-3156.1996.d01-46.x

Affiliations: 1: Departments of Veterinary Parasitology, 2: Groupe de Chimie Organique Biologique, URA au CNRS 470, Université Paul Sabatier, 31062 Toulouse, France 3: Veterinary Medicine, University of Glasgow, Scotland,

Publication date: 1996-06-01

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