A community trial of ivermectin for onchocerciasis in Sierra Leone: compliance and parasitological profiles after three and a half years of intervention

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Abstract:

We have studied the compliance patterns and the long‐term effects of repeated ivermectin at various dosing intervals in a randomized controlled trial. The setting for the trial was six neighbouring communities hyperendemic for onchocerciasis in southern Sierra Leone. A total of 335 subjects attended a survey 18 months after the fifth treatment round. Of those randomized to ivermectin, over 85% had received at least three doses. There was no evidence that women of childbearing age were consistently under‐treated, despite the criteria for exclusion from treatment. An intention‐to‐treat analysis showed that a 6‐monthly ivermectin treatment regime satisfactorily suppressed microfilarial loads. Microfilarial repopulation was significantly slower over an 18‐month period after multiple doses compared to a single dose. Further analysis of microfilarial repopulation suggests that there is a cumulative suppressive effect after at least the first three doses of ivermectin, and that an annual treatment interval is as effective for short‐term microfilarial suppression as a 6‐monthly interval.

Keywords: Sierra Leone; compliance; ivermectin; microfilarial load; onchocerciasis; randomized controlled trial; treatment regimens

Document Type: Original Article

DOI: http://dx.doi.org/10.1046/j.1365-3156.1996.d01-3.x

Affiliations: 1: (analysis): Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK, 2: (fieldwork): Medical Research Council Laboratory, PO Box 81, Bo, Sierra Leone

Publication date: February 1, 1996

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