Synaptic vesicles control the time course of neurotransmitter secretion via a Ca2+/H+ antiport
Source: The Journal of Physiology, Volume 589, Number 1, January 2011 , pp. 149-167(19)
Abstract:Non-technical summary A low-affinity Ca2+/H+ antiport has been described in the membrane of synaptic vesicles isolated from mammalian brain cortex. We show here evidence that the role of the vesicular Ca2+/H+ antiport is to shorten the time course of transmitter release during individual nerve impulses. The process seems of great importance since it can enable rapid synapses to transmit briefer signals, and so work at high frequencies.
Document Type: Research article
Affiliations: 1: Centre for Environmental and Marine Studies (CESAM), Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal. 2: Department of Fundamental Neurosciences, Faculty of Medicine, University of Geneva, CH-1211-Geneva 4, Switzerland
Publication date: 2011-01-01