MR-Guided Intervention in Women at High Hereditary Risk of Breast Cancer Due to both Family and Personal History of Breast Cancer

Authors: Viehweg, Petra¹; Bernerth, Thorsten²; Heinig, Anke²; Kiechle, Marion³; Buchmann, Jörg⁴; Koelbl, Heinz⁵; Laniado, Michael¹; Helen Heywang-Köbrunner, Sylvia

Source: The Breast Journal, Volume 12, Number 6, November/December 2006 , pp. 549-558(10)

Publisher: Wiley-Blackwell

Abstract:

: 

The purpose of this study was to assess the value of magnetic resonance imaging (MRI)-guided intervention in women with a significant hereditary susceptibility to breast cancer due to both family and personal history of breast cancer (heterozygote risk >20%). Thirty women were referred for MR-guided intervention. MR examinations (1.0 T, T1-weighted 3D FLASH, 0.15 mmol Gd-DTPA/kg body weight, prone position) were performed using a system which allows vacuum-assisted breast biopsy or wire localization. Histologic findings in 41 procedures revealed six invasive carcinomas, eight ductal carcinomas in situ and two atypical ductal hyperplasias. Twenty-three benign histologic results were verified by an MR-guided intervention, retrospective correlation of imaging and histology and by subsequent follow-up. In two lesions the indication dropped as the enhancing lesion was no longer visible on the date of planned intervention. Absent enhancement was confirmed by short-term reimaging of the noncompressed breast and by follow-up.

Keywords: breast cancer; early diagnosis; high risk; intervention; magnetic resonance imaging

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1524-4741.2006.00344.x

Affiliations: 1: Institute of Diagnostic Radiology, Technical University Dresden, Dresden 2: Department of Diagnostic Radiology, Martin-Luther-University Halle-Wittenberg, Halle 3: Department of Obstetrics and Gynecology, Technical University Munich, Munich 4: Department of Pathology, Martin-Luther-University Halle-Wittenberg, Halle 5: Department of Obstetrics and Gynecology, Martin-Luther-University Halle-Wittenberg, Halle

Publication date: 2006-11-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Obstetrics & Gynecology ,  Oncology
• By this author: Viehweg, Petra ;  Bernerth, Thorsten ;  Heinig, Anke ;  Kiechle, Marion ;  Buchmann, Jörg ;  Koelbl, Heinz ;  Laniado, Michael ;  Helen Heywang-Köbrunner, Sylvia

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers