IngentaConnect Changes in ejaculatory latency and penile vibratory threshold wit...

Abstract:

Background

SS-cream (severance secret cream) is a topical agent made from extracts of nine natural products for the treatment of primary premature ejaculation (PE). In order to investigate the clinical efficacy of SS-cream, we assessed the ejaculatory latency and penile vibratory threshold of patients with primary premature ejaculation in a double-blind placebo-controlled study.

Method

Thirty-two patients with a mean age of 37.7 ± 6.6 years were randomized into treatment and control groups. Ejaculatory latency and vibration threshold were assessed twice (in both the penile shaft and glans penis) in the screening period, and three times after application of SS-cream or placebo, depending on whether they were in the treatment or control group. The end points for clinical efficacy were defined as a prolonged ejaculatory latency of more than 2 min, and an increased vibration threshold of more than 0.04 microns ( mgr ) after treatment.

Results

In the screening period for the total group the mean ejaculatory latency was assessed at 1.45 ± 0.57 min, while the mean vibratory thresholds of the glans penis and penile shaft were 0.73 ± 0.034 mgr and 0.065 ± 0.034 mgr , respectively. After treatment the mean ejaculatory latency was prolonged to 2.27 ± 2.24 in the placebo group, and 11.06 ± 8.26 min in the SS-cream group. The mean vibratory thresholds were increased to 0.067 ± 0.028 mgr , and 0.100 ± 0.050 mgr at the penile shaft, and 0.080 ± 0.035, and 0.170 ± 0.090 at the glans penis for each group, respectively. In the treatment group the mean ejaculatory latency and mean vibratory thresholds at the glans penis and the penile shaft were significantly improved with the application of SS-cream (P < 0.001). A comparison of the clinical efficacy of placebo and SS-cream, as judged by ejaculatory latency, was 18.8% and 84.0% (respectively), for vibratory threshold 9.0% and 80.0% (respectively) at glans penis, and 0% and 37.0% on the penile shaft (respectively). When examined, there was a significant correlation between vibratory threshold and ejaculatory latency, enhancing the significance of the clinical efficacy of the SS-cream-treated group (P < 0.001).

Conclusions

With these results we conclude that SS-cream increased the penile sensory threshold, and is therefore clinically effective in treating the heightened sensory response in patients with PE.

Changes in ejaculatory latency and penile vibratory threshold with SS-cream in patients with primary premature ejaculation