Beyond Anemia: The Clinical Impact of the Physiologic Effects of Erythropoietin

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In this Subject: <a title="Anatomy & Physiology" href="/content/subcat?j_subject=157&j_availability=">Anatomy & Physiology ,&nbsp; Urology
By this author: Diskin, Charles J. ;&nbsp; Stokes, Thomas J. ;&nbsp; Dansby, Linda M. ;&nbsp; Radcliff, Lautrec ;&nbsp; Carter, Thomas B.

Authors: Diskin, Charles J.; Stokes, Thomas J.; Dansby, Linda M.; Radcliff, Lautrec; Carter, Thomas B.

Source: Seminars in Dialysis, Volume 21, Number 5, September/October 2008 , pp. 447-454(8)

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Abstract:

Although we have known that oxygen tension affects erythrocyte production since the 19th century, we have only recently begun to understand many subtleties of erythropoietin (EPO) physiology. EPO administration has allowed hundreds of thousands of patients to avoid transfusions. With the beneficial effects so apparent a detailed understanding of the full clinical physiology of this plasma factor seemed less important. However, the unanticipated increase in mortality found in recent randomized studies is prompting a reassessment of this view. We will review what is known about the physiology of this plasma factor that, it is now clear, is more than just an erythrocyte production factor.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1525-139X.2008.00443.x

Publication date: 2008-09-01