Neutrophil Dysfunction and Infection Risk in End-Stage Renal Disease

In this: publication
By this: publisher
In this Subject: <a title="Anatomy & Physiology" href="/content/subcat?j_subject=157&j_availability=">Anatomy & Physiology ,&nbsp; Urology
By this author: Chonchol, Michel

Author: Chonchol, Michel

Source: Seminars in Dialysis, Volume 19, Number 4, July 2006 , pp. 291-296(6)

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Abstract:

Infections are still a major cause of morbidity and mortality in end-stage renal disease (ESRD) patients. The susceptibility of ESRD patients to infections is typically ascribed to the immunodeficient state associated with uremia. A central role in the host defense against bacterial infections is played by phagocytic polymorphonuclear white blood cells, which are characterized by the capacity to ingest and subsequently destroy bacteria. Disorders in polymorphonuclear cell function are exacerbated by the dialysis procedure and numerous factors including uremic toxins, iron overload, anemia of renal disease, and dialyzer bioincompatibility. It is concluded that the phagocytic defect observed in ESRD is multifactorial, and each factor should be managed individually with specific therapeutic approaches.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1525-139X.2006.00175.x

Publication date: 2006-07-01