IngentaConnect Systemic antioxidant defences during acute exacerbation of chroni...

Authors: SADOWSKA, AnnaM.; LUYTEN, Chris; VINTS, Anne-Marie; VERBRAECKEN, Johan; RANST, DirkVan; BACKER, WilfriedA. De

Source: Respirology, Volume 11, Number 6, November 2006 , pp. 741-747(7)

Publisher: Blackwell Publishing

Abstract:

Systemic antioxidant defences during acute exacerbation of chronic obstructive pulmonary disease

SADOWSKA AM, LUYTEN C, VINTS A-M, VERBRAECKEN J, Vanranst D, Debacker WA. Respirology 2006; 11: 741-747 Objective and background:

Existence of an increased oxidative stress has been confirmed in patients with acute exacerbation of COPD. This study aims to examine the extent and time-course of antioxidant defence in patients with an acute exacerbation of COPD in comparison with stable patients. Methods:

Twelve patients with acute exacerbation were studied at admission, and then 24 h and 48 h following admission and at discharge. The antioxidants assessed were the endogenous antioxidants: glutathione peroxidase, superoxide dismutase, oxidized and reduced glutathione, albumin and exogenous antioxidants: α-tocopherol and retinol. Trolox equivalent antioxidant capacity as a marker of antioxidant status was also measured. Results:

There was an increase in glutathione peroxidase and superoxide dismutase 48 h after admission (P < 0.05). α-Tocopherol was the lowest 24 h after admission and increased significantly at discharge (P < 0.05). Conclusions:

There is an increase in antioxidant defence during acute exacerbation of COPD reaching a maximum at 48 h after admission. This rise in the antioxidant defence is not sufficient to prevent depletion of non-enzymatic antioxidants such as α-tocopherol.

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