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Successful Reversal of Hyperalgesia/Myoclonus Complex with Low‐Dose Ketamine Infusion

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Abstract:  We report the successful use of low‐dose ketamine infusion for treating a severe episode of painful myoclonus in the lower extremities, associated with opioid‐induced hyperalgesia (OIH), in a patient who was receiving long‐term, high dose intrathecal hydromorphone therapy. A low‐dose ketamine infusion immediately relieved the painful myoclonus. It also enabled a reduction in the intrathecal opioid dosage leading to a resolution of the acute symptoms attributed to OIH.

Document Type: Research Article


Affiliations: 1: Department of Anesthesia, St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada 2: Department of Anesthesia/Chronic Pain Clinic, St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada

Publication date: February 1, 2012

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