Neural fibrolipoma of the superficial peroneal nerve in the ankle: A case report with immunohistochemical analysis

Authors: Akisue, Toshihiro; Matsumoto, Keiji1; Yamamoto, Tetsuji2; Kizaki, Tomohiko3; Fujita, Ikuo1; Yoshiya, Shinichi2; Kurosaka, Masahiro2

Source: Pathology International, Volume 52, Number 11, November 2002 , pp. 730-733(4)

Publisher: Blackwell Publishing

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Abstract:

This report presents a case of neural fibrolipoma arising from the superficial peroneal nerve in the ankle. A 28-year-old woman was referred with a soft tissue mass in the anterior aspect of the right ankle, which had been gradually enlarging for the past 10 years. Magnetic resonance imaging showed a mass lesion, measuring approximately 8 × 3 × 2 cm, with high to partially low signal intensity on both T1- and T2-weighted images. A band of low signal intensity within the lesion, which is indicative of coexistence with the tumor and the superficial peroneal nerve, could be detected on both T1- and T2-weighted images. The patient underwent an excisional biopsy. The specimen microscopically consisted of nerve bundles and fibro-fatty proliferation with abundant collagen fibers. Immunoreactivity for CD34 antigen antibody was detected in fibrous spindle cells. This is the first report to present an immunohistochemical profile of neural fibrolipoma. Neural fibrolipoma should be considered as a differential diagnosis when a lipomatous lesion is encountered in the foot or ankle as well as in the upper extremities.

Keywords: histology; immunohistochemistry; magnetic resonance imaging; neural fibrolipoma; soft tissue tumor

Document Type: Research article

DOI: 10.1046/j.1440-1827.2002.01412.x

Affiliations: 1: Department of Orthopaedic Surgery, Hyogo Medical Center for Adults, Akashi, Japan 2: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan 3: Department of Pathology, Hyogo Medical Center for Adults, Akashi, Japan

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