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Differential regulation of IgG subclasses and IgE antimalarial antibody responses in complicated and uncomplicated Plasmodium falciparum malaria
Authors: TANGTEERAWATANA, P.1; MONTGOMERY, S. M.; PERLMANN, H.2; LOOAREESUWAN, S.3; TROYE-BLOMBERG, M.2; KHUSMITH, S.1
Source: Parasite Immunology, Volume 29, Number 9, September 2007 , pp. 475-483(9)
Publisher: Wiley-Blackwell
Abstract:
SUMMARY The aim of this study was to assess the immunoglobulin (Ig)-subclass distribution of antimalarial antibody responses in 110 and 169 Thai patients with complicated and uncomplicated Plasmodium falciparum malaria, respectively. Antimalarial plasma IgG subclasses and IgE antibody levels against a crude malaria blood stages, and antigen preparation were determined using enzyme-linked immunosorbent assay (ELISA). On admission, the levels of anti-P. falciparum IgG1, IgG2 and IgG3 were significantly lower in patients with complicated malaria than uncomplicated malaria (IgG1, P < 0·0001; IgG2, P < 0·0001; IgG3, P < 0·0001). The levels of antimalarial IgE were slightly lower, but not statistically significant (P = 0·389) in the complicated malaria. After adjusting all antibody levels and age, anti-P. falciparum IgG3 levels remained significantly associated with complicated malaria. None of the other antibody concentrations showed statistically significant associations with complicated malaria. The anti-P. falciparum IgG3 levels were related to the IgG1 as well as IgG2 levels. A correlation between anti-P. falciparum IgG2 and IgE was observed in the complicated malaria group, and this may indicate their roles in the severity of disease. Our data suggest that anti-P. falciparum IgG3 is associated with a reduced risk of complicated malaria and that antimalarial Ig-subclasses are differently regulated in patients with complicated and uncomplicated malaria.Keywords: antibody; complicated malaria; IgE; IgG subclasses; P. falciparum; severity
Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.1365-3024.2007.00965.x
Affiliations: 1: Department of Microbiology and Immunology 2: Department of Immunology, Stockholm University, Stockholm, Sweden 3: Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Publication date: 2007-09-01
- In this: publication
- By this: publisher
- In this Subject: Allergy & Immunology , Internal Medicine
- By this author: TANGTEERAWATANA, P. ; MONTGOMERY, S. M. ; PERLMANN, H. ; LOOAREESUWAN, S. ; TROYE-BLOMBERG, M. ; KHUSMITH, S.
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